|Study Name||Study Contact||Basic Overview||Criteria|
Principal Investigator (PI)-Robert Schultz
Study Coordinator-Lindsey Demarco
|• To connect families and individuals with ASD with autism research studies at the Center for Autism Research (CAR) and affiliated centers.||• Children and adults with and without ASD.|
|Genetic Causes for Complex Pediatric Disorders||
Principal Investigator (PI)-Hakon Hakonarson
Study Coordinator-Meckenzie Behr
|• To study genetic causes for pediatric disorders, both common and rare (Crohn’s, diabetes, ADHD and autism).||• Any child and their parents willing to sign consent and have blood samples obtained.|
|Speech Perception and Word Learning in Early Childhood||
Principal Investigator (PI)-Dan Swingley
Study Coordinator-Elizabeth Crutchley
• To understand how infants and children acquire language.
• To discover what children know about language above and beyond what children reveal through their own speech.
• 6 months – 24 months old.
• No known major hearing loss or known significant visual impairment, no significant mental impairments.
|Improving the Trajectory of Motor Development in Infants and Toddlers with Cerebral Palsy||
Principal Investigator (PI)-Laura Prosser Study Coordinator-Jennifer Swope
|• To learn how two different types of physical therapy affect motor development in toddlers who have or may have cerebral palsy.||• 12-36 months old with diagnosed or suspected cerebral palsy.|
|The SCOUT Study||
Principal Investigator (PI)-Theo Zaoutis
Study Coordinator-Shawn O'Connor
• To determine if halting antimicrobial therapy in subjects who have exhibited clinical improvement 5 days after starting antibiotic therapy (short course therapy) have the same failure rate (symptomatic UTI) through TOC (visit Day 12-14) as subjects who continue to take antibiotics for an additional 5 days (standard course therapy).
• To determine if short-course therapy compared to standard course therapy results in similar numbers of children experiencing a recurrent urinary tract infection (relapse and re-infection).
• <10 years old.
• No history of prematurity.
|Youth Suicide Prevention in Primary Care||
Principal Investigator (PI)-Guy Diamond
Study Coordinator-Tita Atte
• To train physicians in suicide risk assessment.
• To implement a web-based behavioral health screening tool into the workflow of the clinical practice.
• To improve the linkages between the practice and mental health services to that identified patients can get mental health services more easily and rapidly.
|• Any youth presenting with suicidal ideation.|
|Heart Health Screening-ECG screeing Study||
Principal Investigator (PI)-Vicki Vetter
|• To find out if a screening test for heart disease called an electrocardiogram (ECG/EKG) can be used to identify children and adolescents, who might have a form of heart disease that puts them at risk for having a cardiac arrest.||
• Ages 2-6 weeks old.
• Ages 12-19 years old.
Principal Investigator (PI)-Joanne Wood
Study Coordinator-Devon Kratchman
|• To evaluate the efficacy of a group parenting program, PriCARE, for parents of children ages 2-6 years old who are concerned that their child has behavioral problems.||• Parents and caregivers of children ages 2-6 years old who report a behavioral concern.|
|Novel Imaging in Autosomal Recessive Polycystic Kidney Disease (ARPKD)||
Principal Investigator (PI)-Erum Hartung
|• To use brand-new imaging technologies to measure how severely affected the liver and kidneys are in autosomal recessive polycystic kidney disease (ARPKD).||
• Less than 21 years old.
• No history of kidney or liver disease, high blood pressure, blood or autoimmune diseases or obesity.
• No close relatives (siblings or parents) with kidney or liver disease.
Principal Investigator (PI)-Ignacio Tapia
Study Coordinator-Ruth Bradford
• To determine the efficacy of NCS vs. placebo in treating OSAS in children.
• To determine which factors modify the response to NCS, to determine the long-term effect of NCS vs. placebo in the treatment of OSAS in children to determine the side-effects associated with chronic NCS use in children with OSAS.
• 5-10 years old with mild to moderate OSAS.
• No history of adenotonsillectomy or recent prior nasal steroid use.
Principal Investigator (PI)-Juhi Pandey
Study Coordinator-Meredith Cola
|• To determine how children with Autism Spectrum Disorder (ASD) differ from children who are typically developing with respect to: (a) cognitive/behavioral measures of the ASD phenotype; (b) electro- and psychophysiological measures of brain functioning; (c) within-group correlations between behavioral deficits, and biological factors.||
• Toddlers ages 2-5 years old with autism spectrum disorder (ASD) or developmental delay.
• Toddlers ages 2-5 years old who are typically developing.
|Linking, Obesity, Immune Dysfunction and Infection (waiting IRB approval)||
Principal Investigator (PI)-E. John Wherry
• To understand the effect of obesity and asthma on children's ability to respond to their childhood vaccinations and fight infections.
• To understand the effect of obesity and asthma on the immune system.
• Healthy 6-18 years old.
• Weight-<85% or >=95%.
|A Phase IV Double-Blind, Placebo-Controlled, Randomized Trial to Evaluate Short Course vs. Standard Course Outpatient Therapy of Community Acquired Pneumonia in Children (SCOUT-CAP)||
Principal Investigator (PI)-Jeff Gerber
Study Coordinator- Kellie Liston
|• To determine the overall outcome of children aged 6-71 months with community-acquired pneumonia (CAP) assigned to either short course (5 days) versus standard course (10 days) of therapy.||• Children ages 6-71 months diagnosed with community acquired pneumonia.|
|HIT HEADS: Head Injury Treatment with Healthy and Advanced Dietary Supplements for Sports-Related Concussion||
Principal Investigator (PI)-Sage Myers
Study Coordinator-Casey Swan
• To determine whether, compared to placebotreatment, administration of BCAA’s, at one or more doses, after a sports-relatedconcussion improves processing speed recovery at one or more time-periods post concussion.
• To determine whether administration of BCAA’s improves neurocognitive recovery compared to placebo for the cognitive domains of attention, learning, and working memory; to evaluate whether BCAA supplementation improves clinical symptom resolution; and to determine whether BCAA supplementation reduces the time to return to normal activities, specifically school or work, and participationin sports.
• To assess the safety of BCAA supplementation in concussed athletes.
|• 16-34 years old having a concussion within three days.|
|Project EARLY: Engagement, Assessment, Referral, and Linkage for Young Children||
Principal Investigator (PI)-Amanda Bennett-Palladino
Study Coordinator-Manju Abrahams
|• To test the effectiveness of lay-delivered case management (Family Navigation) for children at-risk of having an autism spectrum disorder, as defined by failing MCHAT follow up interview or identified as having concerns for autism by their primary care provider.||• 18 or 24 month old at well child check.|
|MEG Studies of Auditory Processing in Minimally/Non-Verbal Children with ASD and Intellectual Disability||
Principal Investigator (PI)-Tim Roberts
Study Coordinator-Ayesha Anwar
|• To determine if neural biomarkers are generalizable to lower- functioning autism spectrum disoder (ASD) (specifically, minimally/non-verbal).||• Children 8-12 years old who have non-verbal ASD and intellectually delayed children without ASD .|
|Impact of Treatment of Mild Sleep Disorder Breathing on Children's Health (PAT-S)||
Principal Investigator (PI)-Ignacio Tapia
Study Coordinator-Laurie Karamessinis
|• To study the effect of adenotonsillectomy on children with snoring.||• 3-9 years old.|
|Mechanisms of Obstructive Sleep Apnea Syndrome in Infants with Micrognathia||
Principal Investigator (PI)-Chris Cielo
Study Coordinator-Mary Anne Cornaglia
|• To better understand why some children with conditions causing a small jaw (micrognathia) have breathing problems during sleep.||• Healthy patients.|
|Autism Spectrum Disorder Screening in a Large Primary Care Network: Using a Smartphone App to Gather Objective Data at Home, Expand Screening to Preschoolers, and Verify Long Term Outcomes Through The Electronic health Record||
Principal Investigator (PI)-Judi Miller
Study Coordinator-Becca Thomas
• To focus on false negatives. It is precisely this group for whom screening needs to improve –children who screen negative but go on to develop ASD.
• To create objective measures integrated into screening. Current tools rely on caregivers and providers to make behavioral observations that can be difficult even for trained specialists.
• To create tools to expand ASD screening beyond the 16-30 month age range, since the median age of first ASD evaluation is 40 months.
|• All children and families.|
|Pediatrician Message Framing to Protect Children from Secondhand Smoke Exposure||
Principal Investigator (PI)-Brian Jenssen
• To develop an evidence-based message framing approach to promote parental tobacco cessation treatment in the pediatric setting.
• To identify patient and parent factors associated with different patterns of responsiveness to different message frames.
• To examine the association between message frame selection and subsequent tobacco cessation behavior.
|• Parents and caregivers.|
|Beds for Kids Program: Impact on Child Sleep and Family Functioning in Young Children||
Principal Investigator (PI)-Jodi Mindell
Study Coordinator- Ariel Williamson
• To evaluate the impact of provision of a child bed through the Beds for Kids program on objectively measured child sleep, and on daily child behavioral functioning, caregiver mood, and caregiver sleep over 14 days for preschool-aged children.
• To determine the impact of poor child sleep (short sleep duration, later bedtimes, inconsistent bedtimes, night wakings, and poor sleep quality) on daily child behavior, caregiver mood, and caregiver sleep.
• To determine the impact of provision of a child bed through the Beds for Kids program on child sleep at one-month follow-up (one-month post-bed delivery).
|• Children ages 2-5 years old.|
|Improving Human Papillomavirus Vaccination Compliance: An Incentive Program at the Children's Hospital of Philadelphia Karabots Pediatric Care Center||
Principal Investigator (PI)-Kari Draper
Study Coordinator-Leah Quinn
|• The objective of the study is to determine the effectiveness of incentive in increasing HPV vaccine compliance rates of young adolescents at the CHOP Karabots Pediatric Care Center.||• Patients eligible for the 2nd dose of HPV vaccine.|
|Observational Genetic Nephrolithiasis Risk Determination||
Principal Investigator (PI)-Jeff Roizen
Study Coordinator-Sheri McDougall
|• To see if there are genes associated with kidney stone risk and to determine if a spot urine test is effective as a 24-hour urine test.||
• 6-9 years old who may or may not have asthma, obesity and/or ADHD.
• Family history with or without kidney stones.
• Caucasian or African American.
|West Philadelphia Asthma Care Imlementation Plan||
Principal Investigator (PI)-Tyra Bryant-Stephens
Study Coordinator-Yolanda Williams
|• To use community health workers or lay health educators to implement asthma interventions in the clinic, home and school that have been proven to work in order to connect the caregiver, community, school and health sectors.||• 1-16 years old|
|Development of an Intervention to Promote Parent-Teen Communication about Teen Strengths for use in Primary Care||
Principal Investigator (PI)-Victoria Miller
Study Coordinator-Elizabeth Friedrich
|• To develop and refine the content of a Strength Intervention based on prior research related to character development, subject matter experts, and feedback from parents and adolescents.||• 13-15 years old scheduled for a well child visit accompanied by parent.|
|Flu2Text: A Multi-Site Study Assessing an Intervention for 2nd Dose of Influenza Vaccine||Principal Investigator (PI)-Alex Fiks
Study Coordinator-Katya Nekrasova
|• To compare the impact on receipt of the second dose of influenza vaccine of conceptually grounded and personalized text message reminders among children in need of a second dose of influenza vaccine.||• Children receiving the flu vaccine for the first time.|
|How to Engage Urban Adolescent Black Males and Their Caregivers in Preventive Health Services: A Qualitative Analysis||Principal Investigator (PI)-George Dalembert
|• To understand what (self-identified) black teenage boys and their parents/caregivers think, feel, and believe about check-ups.||• Black males ages 13-18 years old with no complex chronic medical conditions.|
|Adolescent Mood Project: Preventing Adolescent Depression in Primary Care||Principal Investigator (PI)-Jami Young
Study Coordinator- Morgan Bush and Rebecca Kanine
Phone-267-425-1323 and 267-425-1327
Email- firstname.lastname@example.org and email@example.com
|• To examine the feasibility, acceptability, and preliminary efficacy of delivering an evidence-based depression prevention program in primary care.
• To collect data to provide information on how this interpersonal prevention program works.
• To examine the feasibility of using ecological momentary assessment (EMA) to optimize the timing and content of post-intervention booster sessions.
|• Adolescents with elevated depressive symptoms.|
|Space-Time Study of Youth and School Violence||Principal Investigator (PI)-Doug Wiebe
Study Coordinator- Bernadete D'Alonzo
|• To learn more about how school environments contribute to violence, and how to work with schools to make environments safer.||• 12-18 years old|
|Health Policy: Should We Talk About It?||Principal Investigator (PI)-Chen Kenyon
Study Coordinator- Sindhi Pandurangi
|• To explore patient/family preferences in discussing health policy issues with their providers.||• Providers and residents|
|The Lifespan Brain Institute Screening and Intake Protocol||Principal Investigator (PI)-Raquel Gur
Study Coordinator- Nina Laney
|• To learn how the brain and behavior change over time and in response to different mental illnesses.||• 10-17 years old with mental health illness (including ADHD) as well as healthy children.|
|Health Coaching for Contraceptive Continuation (HC3) in the U.S.-A Pilot Efficacy Trial||Principal Investigator (PI)-Aletha Akers
Study Coordinator- Kezia Barnett
|• To compare contraceptive continuation rates, contraceptive adherence rates, change in reproductive health outcomes (condom negotiation, healthy relationships, and prevention of HIV and sexually transmitted infections), and satisfaction with birth control among young women receiving the Health Coaching for Contraceptive Continuation(HC3) intervention as compared to a standard of care control group.||• 14-22 years old|
|HPV Mobile Phone App Study||Principal Investigator (PI)-Anne Teitelman
Study Coordinator- N/A
|• To test a parent and provider intervention to improve human papillomavirus (HPV) vaccine uptake among adolescents.
• To develop a mobile phone-based application for parents, and an educational video webcast and point-of-care cue reminders for clinicians, designed to promote HPV vaccine uptake.
• To evaluate the influence of the interventions on parents and clinicians as well as rates of HPV vaccine initiation and completion across the network.
|• 11-12 years old that has not initiated the HPV vaccine series.|