Study Name Study Contact Basic Overview Criteria
Genetic Causes for Complex Pediatric Disorders Principal Investigator (PI)-Hakon Hakonarson
Study Coordinator-Meckenzie Behr
• To study genetic causes for pediatric disorders, both common and rare (Crohn’s, diabetes, ADHD and autism). • Any child and their parents willing to sign consent and have blood samples obtained.
Speech Perception and Word Learning in Early Childhood Principal Investigator (PI)-Dan Swingley
Study Coordinator-N/A
• To understand how infants and children acquire language.
• To discover what children know about language above and beyond what children reveal through their own speech.
• 6 months – 24 months old.
• English-speaking.
• No known major hearing loss or known significant visual impairment, no significant mental impairments.
Improving the Trajectory of Motor Development in Infants and Toddlers with Cerebral Palsy Principal Investigator (PI)-Laura Prosser
Study Coordinator-Jennifer Swope
• To learn how two different types of physical therapy affect motor development in toddlers who have or may have cerebral palsy. • 12-36 months old with diagnosed or suspected cerebral palsy.
Youth Suicide Prevention in Primary Care Principal Investigator (PI)-Guy Diamond
Study Coordinator-Tita Atte
• To train physicians in suicide risk assessment.
• To implement a web-based behavioral health screening tool into the workflow of the clinical practice.
• To improve the linkages between the practice and mental health services to that identified patients can get mental health services more easily and rapidly.
• Any youth presenting with suicidal ideation.
PriCare Study Principal Investigator (PI)-Joanne Wood
Study Coordinator-Devon Kratchman
• To evaluate the efficacy of a group parenting program, PriCARE, for parents of children ages 2-6 years old who are concerned that their child has behavioral problems. • Parents and caregivers of children ages 2-6 years old who report a behavioral concern.
Novel Imaging in Autosomal Recessive Polycystic Kidney Disease (ARPKD) Principal Investigator (PI)-Erum Hartung
Study Coordinator-N/A
• To use brand-new imaging technologies to measure how severely affected the liver and kidneys are in autosomal recessive polycystic kidney disease (ARPKD). • Less than 21 years old.
• No history of kidney or liver disease, high blood pressure, blood or autoimmune diseases or obesity.
• No close relatives (siblings or parents) with kidney or liver disease.
ROADD Study (on hold) Principal Investigator (PI)-Juhi Pandey
Study Coordinator-Meredith Cola
• To determine how children with Autism Spectrum Disorder (ASD) differ from children who are typically developing with respect to: (a) cognitive/behavioral measures of the ASD phenotype; (b) electro- and psychophysiological measures of brain functioning; (c) within-group correlations between behavioral deficits, and biological factors. • Toddlers ages 2-5 years old with autism spectrum disorder (ASD) or developmental delay.
• Toddlers ages 2-5 years old who are typically developing.
Linking, Obesity, Immune Dysfunction and Infection (waiting IRB approval) Principal Investigator (PI)-E. John Wherry; Co-Investigator-Sarah Henrickson
Study Coordinator-N/A
• To understand the effect of obesity and asthma on children's ability to respond to their childhood vaccinations and fight infections.
• To understand the effect of obesity and asthma on the immune system.
• Healthy 6-18 years old.
• Weight-=95%.
A Phase IV Double-Blind, Placebo-Controlled, Randomized Trial to Evaluate Short Course vs. Standard Course Outpatient Therapy of Community Acquired Pneumonia in Children (SCOUT-CAP) Principal Investigator (PI)-Jeff Gerber
Study Coordinator- Kellie Liston
• To determine the overall outcome of children aged 6-71 months with community-acquired pneumonia (CAP) assigned to either short course (5 days) versus standard course (10 days) of therapy. • Children ages 6-71 months diagnosed with community acquired pneumonia.
HIT HEADS: Head Injury Treatment with Healthy and Advanced Dietary Supplements for Sports-Related Concussion Principal Investigator (PI)-Sage Myers
Study Coordinator-Casey Swan
• To determine whether, compared to placebotreatment, administration of BCAA’s, at one or more doses, after a sports-relatedconcussion improves processing speed recovery at one or more time-periods post concussion.
• To determine whether administration of BCAA’s improves neurocognitive recovery compared to placebo for the cognitive domains of attention, learning, and working memory; to evaluate whether BCAA supplementation improves clinical symptom resolution; and to determine whether BCAA supplementation reduces the time to return to normal activities, specifically school or work, and participationin sports.
• To assess the safety of BCAA supplementation in concussed athletes.
• 16-34 years old having a concussion within three days.
Impact of Treatment of Mild Sleep Disorder Breathing on Children's Health (PAT-S) Principal Investigator (PI)-Ignacio Tapia
Study Coordinator-Laurie Rosenthal
• To study the effect of adenotonsillectomy on children with snoring. • 3-9 years old.
Mechanisms of Obstructive Sleep Apnea Syndrome in Infants with Micrognathia Principal Investigator (PI)-Chris Cielo
Study Coordinator-Mary Anne Cornaglia
• To better understand why some children with conditions causing a small jaw (micrognathia) have breathing problems during sleep. • Healthy patients.
Autism Spectrum Disorder Screening in a Large Primary Care Network: Using a Smartphone App to Gather Objective Data at Home, Expand Screening to Preschoolers, and Verify Long Term Outcomes Through The Electronic health Record Principal Investigator (PI)-Judi Miller
Study Coordinator-Becca Thomas
Phone- 267-425-1160
• To focus on false negatives. It is precisely this group for whom screening needs to improve –children who screen negative but go on to develop ASD.
• To create objective measures integrated into screening. Current tools rely on caregivers and providers to make behavioral observations that can be difficult even for trained specialists.
• To create tools to expand ASD screening beyond the 16-30 month age range, since the median age of first ASD evaluation is 40 months.
• All children and families.
BE Smokefree: Behavioral Economics Incentives to Engage Adolescents in Smoking Cessation Principal Investigator (PI)-Brian Jenssen
Study Coordinator-N/A
Phone- 215-553-4390
• To compare, through a pilot, randomized controlled trial, a reward-based, loss-framed or no financial incnetive intervention on adolescent smoker enrollment and depth of engagement in a smoking cessation program (Free Smoker Quitline).
• To compare cotinine-confirmed (ie: a slavia swab that measures the amount of nicotine) 4-week quit rates across the 3 groups, among users who report quitting smoking.
• 14-17 years old who currently use tobacco products and express an interest in quitting.
• Access to a smart phone.
Pediatrician Message Framing to Protect Children from Secondhand Smoke Exposure Principal Investigator (PI)-Brian Jenssen
Study Coordinator-N/A
• To develop an evidence-based message framing approach to promote parental tobacco cessation treatment in the pediatric setting.
• To identify patient and parent factors associated with different patterns of responsiveness to different message frames.
• To examine the association between message frame selection and subsequent tobacco cessation behavior.
• Parents and caregivers.
Beds for Kids Program: Impact on Child Sleep and Family Functioning in Young Children Principal Investigator (PI)-Jodi Mindell
Study Coordinator- Ariel Williamson
• To evaluate the impact of provision of a child bed through the Beds for Kids program on objectively measured child sleep, and on daily child behavioral functioning, caregiver mood, and caregiver sleep over 14 days for preschool-aged children.
• To determine the impact of poor child sleep (short sleep duration, later bedtimes, inconsistent bedtimes, night wakings, and poor sleep quality) on daily child behavior, caregiver mood, and caregiver sleep.
• To determine the impact of provision of a child bed through the Beds for Kids program on child sleep at one-month follow-up (one-month post-bed delivery).
• Children ages 2-5 years old.
Observational Genetic Nephrolithiasis Risk Determination Principal Investigator (PI)-Jeff Roizen
Study Coordinator-Sheri McDougall
• To see if there are genes associated with kidney stone risk and to determine if a spot urine test is effective as a 24-hour urine test. • 6-9 years old who may or may not have asthma, obesity and/or ADHD.
• Family history with or without kidney stones.
• Caucasian or African American.
West Philadelphia Asthma Care Imlementation Plan Principal Investigator (PI)-Tyra Bryant-Stephens
Study Coordinator-Yolanda Williams
• To use community health workers or lay health educators to implement asthma interventions in the clinic, home and school that have been proven to work in order to connect the caregiver, community, school and health sectors. • 1-16 years old
Implementing Patient-Centered Medical Home-Based Free Community Tax Preparation Principal Investigator (PI)-George Dalembert
Study Coordinator-N/A
• To describe the impact of implementing free tax preparation services, including the feasibility and acceptability of offering the service in the clinic setting, and to identify barriers and facilitators for the service. • All families that meet the IRS criteria for this program.
Space-Time Study of Youth and School Violence Principal Investigator (PI)-Doug Wiebe
Study Coordinator- Bernadete D'Alonzo
Phone- 215-898-4736
• To learn more about how school environments contribute to violence, and how to work with schools to make environments safer. • 12-18 years old
Health Policy: Should We Talk About It? Principal Investigator (PI)-Chen Kenyon
Study Coordinator- Sindhi Pandurangi
Phone- 267-216-7705
• To explore patient/family preferences in discussing health policy issues with their providers. • Providers and residents
The Lifespan Brain Institute Screening and Intake Protocol Principal Investigator (PI)-Raquel Gur
Study Coordinator- Nina Laney
Phone- 215-615-3290
• To learn how the brain and behavior change over time and in response to different mental illnesses. • 10-17 years old with mental health illness (including ADHD) as well as healthy children.
Health Coaching for Contraceptive Continuation (HC3) in the U.S.-A Pilot Efficacy Trial Principal Investigator (PI)-Aletha Akers
Study Coordinator- Danielle Sands
Phone- 467-525-1320
• To compare contraceptive continuation rates, contraceptive adherence rates, change in reproductive health outcomes (condom negotiation, healthy relationships, and prevention of HIV and sexually transmitted infections), and satisfaction with birth control among young women receiving the Health Coaching for Contraceptive Continuation(HC3) intervention as compared to a standard of care control group. • 14-22 years old.
Open Doors to Early Intervention Principal Investigator (PI)-Jim Guevara
Study Coordinator- Sherry Winston
Phone- N/A
• To test the effectiveness of the Opening Doors to Early Intervention Program on early intervention initiation and completion among children residing in an urban community.
• To assess whether parent engagement in early intervention mediates the effects of the program on early intervention initiation and completion.
• To determine if English proficiency, health literacy, or neighborhood poverty moderate the effects of the program on early intervention initiation and completion.
• To explore the effects of the Opening Doors to Early Intervention Program on developmental status
• < 30 months old.
• Live in the Philadelphia area.
• Identified as developmentally at risk.
Altered Brain Structure and Function in Adolescents with Behaviorally Acquired HIV Principal Investigator (PI)-Jen McGuire
Study Coordinator- Jacqueline Harrison
Phone- 267-425-3079
• To learn more about how HIV affects an adolescent's thinking, memories, language, and brain growth. • 16 -20 years old with and without HIV.
Patient Experiences with IUD Insertion Study Principal Investigator (PI)-Aletha Akers
Study Coordinator- Ava Akolnik
Phone- 215-590-2471
• To gain an in-depth understanding of decisions to use and experiences using a hormonal intrauterine device (IUD) and to obtain feedback regarding recommendations for effective contraceptive counseling and clinical management. • 14-24 years old.
Flu2Text: A Multi-Site Study Assessing an Intervention for 2nd Dose of Influenza Vaccine Principal Investigator (PI)-Alex Fiks
Study Coordinator-Katya Nekrasova
• To compare the impact on receipt of the second dose of influenza vaccine of conceptually grounded and personalized text message reminders among children in need of a second dose of influenza vaccine. • Children receiving the flu vaccine for the first time.
Increasing Childhood Sleep Duration in the Primary Care Setting Principal Investigator (PI)-Jonathan Mitchell
Study Coordinator-Nick Huffnagle
• To develop and test strategies to encourage children to increase their sleep duration. • 9-12 years old who typically sleep between 6-8.5 hours per night.
PREVENTION OF URINARY STONES WITH HYDRATION (PUSH): A Randomized Clinical Trial to Investigate the Impact of Increased Fluid Intake and Increased Urine Output on the Recurrence Rate of Urinary Stone Disease (USD) in Adults and Children Principal Investigator (PI)-Greg Tasian
Study Coordinator-Brittney Henderson
• To determine whether a behavioral intervention to increase fluid intake will result in reduced risk of stone reoccurrence over a 2-year period. • 12 years old or > and have passed a kidney stone or had surgery for kidney stones in the past 3 years.
Intimate Partner Violence Screening in a Pediatric Primary Care Center Principal Investigator (PI)-Ashlee Murray
Study Coordinator-Jessica Dubois
• To adapt and implement a successful screening process that measures IPV experiences of adults who bring their children to the CHOP Karabots Primary Care Center.
• To evaluate and test the provider acceptability of a PCC-based IPV screening tool.
• To evaluate the impact of the IPV screening tool on PCC workflow and patient outcomes in the CHOP PCC.
• All patients and families who come to Karabots for a routine well-child visit.
Cardiometabolic Health in Adolescents of South Asian Ancestry - The CHAriSmA Study Principal Investigator (PI)-Andrea Kelly
Study Coordinator-Claire Cochrane
• To look at ancestry related differences in the risks of developing cardiovascular disease and type 2 diabetes risk. • 15-21 years old.
• African American, South Asian and Caucasian ancestry groups.
How Do Novel Seat Positions Impact Usability of Child Restraints? Principal Investigator (PI)-Aditya Belwaldi
Study Coordinator-Shreyas Sarfare
• To assess the importance of seat orientation upon installation and removal of different types of Child Restraint Systems (CRS).
• To understand how seat orientation, position and configuration impact the comfort of passengers in autonomous vehicles, particularly when some passengers require CRS.
• To collect parents’ judgments about how seat orientation and configuration impact their ability to use CRS, including how confident they feel that children will be safely restrained with different possible configurations.
• 8 years old or younger
SPARK: Simons Foundation Powering Autism Research for Knowledge Principal Investigator (PI)-Bob Schultz
Study Coordinator-Samiza Palmer
• To understand why minority families are participating in research less, what barriers to research they experience and find out how researchers can address those barriers to make research participation more inclusive. • Diagnosis of autism spectrum disorder.