Listing

Study Name Study Contact Basic Overview Criteria
Magnetoencephalographic Studies of Lexical Processing and Abstraction in Autism Spectrum Disorders Principal Investigator (PI)-Tim Roberts

Study Coordinator-Katherine Hines

Phone-215-590-0916

Email- MEGstudies@email.chop.edu

  • To understand how a child’s brain processes sounds, words and pictures.
  • To study brain activity differences between children with ASD and children with typical development.
  • 6-15 years old with a diagnosis of ASD with language impairment.
  • 6-15 years old.
  • Typical developing.
autismMatch Principal Investigator (PI)-Robert Schultz

Study Coordinator-Julianne Fretz

Phone-866-570-6524

Email- autism@email.chop.edu

  • To connect families and individuals with ASD with autism research studies at CAR and affiliated centers.
  • Children and adults with and without ASD.
Neuropsychological, Neural, and Genetic Basis of Cognitive Control in ASD Principal Investigator (PI)-Benjamin Yerys

Phone-866-570-6524

Email- autism@email.chop.edu

  • To correlate neuropsychological features, brain imaging features, and genetic risk factors in individuals with ASD and a typically developing (TDC) matched on age, gender-ratio, parental education, and general cognitive ability.
  • 6-17 years old.
  • English child’s primary language.
  • ASD diagnosis.
Genetic Causes for Complex Pediatric Disorders Principal Investigator (PI)-Hakon Hakonarson

Study Coordinator-Rosetta Chiavacci

Phone-267-426-0653

Email- chiavacci@email.chop.edu

  • To study genetic causes for Pediatric Disorders, both common and rare (Crohn’s, diabetes, ADHD and autism).
  • Any child and their parents willing to sign consent and have blood samples obtained.
Speech Perception and Word Learning in Early Childhood Principal Investigator (PI)-Dan Swingley

Study Coordinator-Elizabeth Crutchley

Phone-215-746-0060

Email- este@sas.upenn.edu

  • To understand how infants and children acquire language.
  • To discover what children know about language above and beyond what children reveal through their own speech.
  • 6 months – 2 years old.
  • English-speaking.
  • No known major hearing loss or known significant visual impairment, no significant mental impairments.
Change and Stability in Risk and Protective Factors Principal Investigator (PI)-Sara Jaffee

Study Coordinator-Tanya Datta

Phone-215-746-2495

Email- tanyada@sas.upenn.edu

  • To identify change and stability over 12 months in risk and protective factors as a function of exposure to family adversity.
  • To conduct qualitative interviews with adolescents to learn what resources or individual characterisitics they think protect adolescents from poor school performance and engagin in health risk behaviors.
  • English speaking 14-16 year olds with no cognitive disablitlies.
The SCOUT Study Principal Investigator (PI)-Theo Zaoutis

Study Coordinator-Shawn O'Connor

Phone-267-426-5292

Email- oconnors1@email.chop.edu

  • To determine if halting antimicrobial therapy in subjects who have exhibited clinical improvement 5 days after starting antibiotic therapy (short course therapy) have the same failure rate (symptomatic UTI) through TOC (visit Day 12-14) as subjects who continue to take antibiotics for an additional 5 days (standard course therapy).
  • To determine if short-course therapy compared to standard course therapy results in similar numbers of children experiencing a recurrent urinary tract infection (relapse and re-infection).
  • <10 years old.
  • No history of prematurity.
Family Safety Net Principal Investigator (PI)-Guy Diamond

Study Coordinator-Jody Russon

Phone-215-571-3406

Email- jmr439@drexel.edu

  • The primary objective of this study is to compare the efficacy of Attachment Based Family Therapy (ABFT) to Family enhanced Non-Directive Supportive Therapy (FE-NST) for reducing suicide ideation at post treatment (16 weeks) and follow up (32 and 52 weeks).
  • The secondary objective is to compare the efficacy of ABFT to FE-NST for reducing secondary outcomes including suicide ideation, impression and family conflict at post treatment (16 weeks and follow-up 32 and 52 weeks).
  • 14-24 years old.
Youth Suicide Prevention in Primary Care Principal Investigator (PI)-Guy Diamond

Study Coordinator-Tita Atte

Phone-215-571-3416

Email- tita.atte@drexel.edu

  • To train physicians in suicide risk assessment.
  • To implement a web-based behavioral health screening tool into the workflow of the clinical practice.
  • To improve the linkages between the practice and mental health services to that identified patients can get mental health services more easily and rapidly.
  • Any youth presenting with suicidal ideation.
A Peer-Based, Social-Media Enabled Intervention to Promote Healthy Growth in Infancy Principal Investigator (PI)- Alex Fiks

Study Coordinator-Rachel Gruver

Phone-267-426-7591

Email- gruverr@email.chop.edu

  • To develop a peer-based, social media-enabled intervetion to prevent obesity in partnership with the target population of low-income mothers at high risk of having obese chilren, and with pediatricians.
  • To pilot test the intervention to establish feasibility, acceptability, and explore its impact on target outbomex, including behaviors associate with healthy growth.
  • Maternal BMI >=25 at <18wks, gestational age >= 20 wks, and maternal age >=18.
  • Medicaid/Medical Assistance insurance.
  • Plan to receive pediatric primary care at CHOP Care Network site.
  • Has a smartphone with texting/data plan and has used phone to obtain photos/videos.
  • Able to speak, read & write in English, able to provide informed consent.
  • Singleton pregnancy, no severe morbidity, no current dx or significant history of major mental illness.
Antibiotic Management of Outpatient Pediatric UTI’s Principal Investigator (PI)-Jeff Gerber

Study Coordinator-Carter Cowden

Phone-267-426-7668

Email- cowdenc@email.chop.edu

  • Examine management patterns for UTI’s across CHOP Care Network.
  • All children with UTI diagnosis.
Cardiometabolic risk and obesity in adolescents with Down syndrome Principal Investigator (PI)-Sheela Magge

Study Coordinator-Divya Prasad

Phone-267-426-2778

Email- prasadd@email.chop.edu

  • To compare the relationship between BMI-Z score and cardiometabolic risk factors in youth with DS, and in age, sex, race, ethnicity and BMI-Z score matched controls.
  • To examine the relationship between obesity, lifestyle (physical activity, nutrition), body image, and quality of life in DS, and to explore barriers to maintaining a healthy weight in children with DS.
DS Group
  • Males and females age 10 to 20 years.
  • Diagnosis of DS.
  • Parental/guardian permission (informed consent) and if appropriate, child assent.

    Control Group

  • Males and females age 10 to 20 years.
  • Parental/guardian permission (informed consent) and if appropriate, child assent.
  • Health Outcomes and Healthcare utilization among Food Insecure Children in Primary Care Pracitce Principal Investigator (PI)-Alex Fiks

    Study Coordinator-Deepak Palakshappa

    Phone-617-694-4375

    Email- palakshappad@email.chop.edu

    • To determine the association of food insecurity with negative health outcomes in children.
    • To evaluate the rates of food insecurity screening at a large children's hospital care network.
    • To evaluate the effect of food insecurity on child growth.
    • To evaluate the effect of food insecurity on child development and behavioral problems.
    • To evaluate the effect of food insecurity on laboratory abnormalities.
    • To evaluate the effects of food insecurity on healthcare utilization.
    • Retrospective chart review
    A Pilot Study Evaluating the Transmission and Early Viral Dynamics in Maternal-Fetal Transmission of Hepatitis C Virus Principal Investigator (PI)-Jessica Wen

    Study Coordinator-Lindsay Brown

    Phone-267-426-0970

    Email- brownl7@email.chop.edu

    • To examine the complexity of the HCV viral genome circulating in infected infants and to quantify the number of individual HCV species leading to productive clinical infection in mother to child HCV transmission using a novel viral sequencing. This will help gain better insights into the barrier an vaccine or prophylaxis medication must overcome to be successful in preventing HCV transmission.
    • Infants 6 months and younger born to mothers with Hepatitis C.
    Dietary Fructose, Zinc, and Nephrolithiasis Principal Investigator (PI)-Gregory Tasian

    Study Coordinator-Lauren Vernau (Chorney)

    Phone-267-426-2586

    Email- chorneyl@email.chop.edu

    • To determine the differences in fructose and zinc intake between adolescents with and without calcium oxalate nephrolithiasis.
    • To determine the relationship between dietary fructose and zinc intake and urine chemistries among adolescents.
    • Healthy adolescents ages 12-18 years old.
    Interactive point-of care digital video as a tool to improve HPV vaccination rates among adolescents Principal Investigator (PI)-Kristen Feemster

    Study Coordinator-Caitlin Fasano

    Phone-215-590-9366

    Email- fasanoce@email.chop.edu

    • To assess the impact of an interactive point-of-care digital video program (RFO or Recipe for Outcomes) targeting HPV vaccines within a primary care setting.
    • Healthy adolescentseligible for HPV vaccination during a scheduled primary care visit.
    Influenza Vaccine Responsiveness In Young Children Principal Investigator (PI)-Kristen Feemster

    Study Coordinator-Muida Menon

    Phone-267-426-0191

    Email- menonm@email.chop.edu

    • To compare antibodies in sera from children vaccinated with 2 doses of influenza vaccine from the same season with sera from children vaccinated with 2 doses of influenza vaccine from two different seasons.
    • To determine if children mount
      different immune responses following two vaccinations in the same influenza season versus two influenza vaccinations in two different influenza seasons.
    • Infants at least 6 months old who have not received the influenza vaccine previously.
    Educating and Supporting Primary Care Providers in the Implementation of Evidence-based Practices for ADHD Principal Investigator (PI)-Tom Power

    Study Coordinator-Stephanie Mayne

    Phone-267-426-5257

    Email- maynes@email.chop.edu

    • To educate primary care providers to Increase the use of evidence-based practices for managing ADHD.
    • All primary care providers.
    Novel Imaging in Autosomal Recessive Polycystic Kidney Disease (ARPKD) Principal Investigator (PI)-Erum Hartung

    Study Coordinator-N/A

    Phone-267-908-2297

    Email- hartunge@email.chop.edu

    • To use brand-new imaging technologies to measure how severely affected the liver and kidneys are in autosomal recessive polycystic kidney disease (ARPKD).
    • Less than 21 years old.
    • No history of kidney or liver disease, high blood pressure, blood or autoimmune diseases or obesity.
    • No close relatives (siblings or parents) with kidney or liver disease.
    Web-Based Risky Driving Principal Investigator (PI)-Flaura Winston

    Study Coordinator-Katherine McDonald

    Phone-215-746-0392

    Email- mcdonaldc@email.chop.edu

    • To assess the feasibility of a web-based risky driving intrevention at follow up on simulated driving performance, self-reported driving behaviors, and driving citations and crashes.
    • 16-17 years old.
    SPARKS Principal Investigator (PI)-Carole Marcus

    Study Coordinator-Ruth Bradford

    Phone-267-426-5747

    Email- bradford@email.chop.edu

    • To determine the efficacy of NCS vs. placebo in treating OSAS in children.
    • To determine which factors modify the response to NCS, to determine the long-term effect of NCS vs. placebo in the treatment of OSAS in children to determine the side-effects associated with chronic NCS use in children with OSAS.
    • 5-10 years old with mild to moderate OSAS.
    • No history of adenotonsillectomy or recent prior nasal steroid use.
    Study of Pain Control with Hormonal IUS Insertion (SOPHI Study) Principal Investigator (PI)-Aletha Akers

    Study Coordinator-Caren Steinway

    Phone-267-426-9267

    Email- steinwayc@email.chop.edu

    • To find out if use of a medication nerve block versus a sham (no medication) block reduces pain during insertion of the Skyla® hormonal intrauterine system (IUS) among young women.
    • 14-22 year old females.
    Social Media Intervention to Teach Parenting to Women with Postpartum Depression Principal Investigator (PI)-Jim Guevara

    Study Coordinator-Jordan Price

    Phone-267-426-7947

    Email- pricej3@email.chop.edu

    • To develop a parent coaching program for women with postpartum depressive symptoms utilizing a social media format to enhance participation.
    • To assess the feasiblity and acceptability of the social media program compared to a traditional group format.
    • To explore outcomes related to each format.
    • Women with postpartum depressive symptoms.
    Comparative Effectiveness of Antibiotics for Respiratory Infections (CEARI) Principal Investigator (PI)-Jeff Gerber

    Study Coordinator-Folasade Odeniyi

    Phone-267-426-9727

    Email- odeniyif@email.chop.edu

    • To investigate what parents think about antibiotic therapy, specifically what outcomes they worry about when their child is sick with an acute respiratory tract infection (ARTI)
    • Parents of children 3 months-18 years old who present with symptoms consistent with ARTI.
    Preceptions about Public Assistance Programs Principal Investigator (PI)-Chris Feudnter

    Study Coordinator-Deepak Palakshappa

    Phone-267-250-8644

    Email- palakshappad@email.chop.edu

    • To describe caregivers' perception of screening and referral for public assistance programs as part of the primary care visit.
    • Families who screened postive for food insecurity.
    Linking, Obesity, Immune Dysfunction and Infection Principal Investigator (PI)-E. John Wherry
    Co-Investigator-Sarah Henrickson

    Study Coordinator-Donnette Paris

    Phone-267-426-7167

    Email- paris@email.chop.edu

    • To understand the effect of obesity and asthma on children's ability to respond to their childhood vaccinations and fight infections.
    • To understand the effect of obesity and asthma on the immune system.
    • Healthy 6-18 years old.
    • Weight-<85% or >=95%.
    Adapting Behavior Change Interventions for Use in Primary Care Principal Investigator (PI)-Carol Ford

    Study Coordinator-Courtney Cheek

    Phone-267-426-3934

    Email- cheekc@email.chop.edu

    • To get parent's opinions about the content of parent-based intervention materials related to teen health behaviors.
    • To gather parent's ideas about how best to give out the intervention materials in primary care settings.
    • To get parent's feedback about participation in research related to teen health behaviors.
    • To create materials that are useful and acceptable to parents and that may be easily delivered in heathcare settings based on the information gathered.
    • Parent's of 12-17 year olds.
    Implementation of an Outpatient Antimicrobial Stewardship Program Principal Investigator (PI)-Jeff Gerber

    Study Coordinator-Suratha Elango

    Phone-210-288-1563

    Email- elangos@email.chop.edu

    • To reduce the use of antibiotics that are stronger than needed (and can cause more side effects and antibiotic resistance).
    • To use an existing validated survey on doctors to measure
      organizational readiness to change.
    • To identify barriers and facilitators to readiness to change from in-depth interviews with doctors at high and low readiness to change clinics.
    • To identify potential ways to address the barriers to readiness to change identified above.
    • To explore the rate of change of broad spectrum antibiotic use at high vs lowreadiness to change clinics at 3, 6, and 9 months after the start of the intervention
    • Providers at CHOP Care
      Network Sites.
    The Development of Tests of Lung Function in Preschool Children with Asthma Principal Investigator (PI)-Julian Allen

    Study Coordinator-Michele Bergman

    Phone-217-425-2111

    Email- bergman@email.chop.edu

    • To assess the usefulness and accuracy of two different types of lung function testing in preshcool children.
    • 16 year old or older that had a sports physical in the last year or two.
    Optical Measurement of Cerebral Hemodynamics in Children with Acute Arterial Ischemic Stroke Principal Investigator (PI)-Dan Licht

    Study Coordinator-Kobina Mensah-Brown

    Phone-

    Email- mensahbrok@email.chop.edu

    • The primary objectives are to determine the variability of CBF in healthy children as HOB position is altered and to determine whether noninvasive monitoring with optical spectroscopy can detect changes in cerebral blood flow as the HOB angle is varied over a range from -5 to +30 degrees in children with ischemic stroke.
    • The secondary objective is to determine if the position that maximizes CBF varies over time from stroke onset.
    • Healthy children ages 2-18 years old.
    The Human Immune Response to Chlamydia Trachomatis Principal Investigator (PI)-Laura Vella

    Study Coordinator-Laura Vella

    Phone-412-848-7461

    Email- vellal@email.chop.edu

    • To provide information that will help make a vaccine to prevent Chlamydia infection. The body has difficulty fighting off the Chlamydia bacteria, and a person can get have the infection for a long period of time and can get the infection over and over again. We want to study why the immune system doesn't work well against Chlamydia. We also want to see which protein parts of the Chlamydia are the easiest for the immune system to fight.
    • Males or Females presenting without parent to the Family Planning Clinic with indication fro Chlamydia testing and HIV testing.
    • Ability of the minor to consent for him or herself.
    HIT HEADS: Head Injury Treatment with Healthy and Advanced Dietary Supplements for Sports-Related Concussion Principal Investigator (PI)-Matt Kircshen

    Study Coordinator-Jaclynn Elkind

    Phone-267-432-2862

    Email- elkindj1@email.chop.edu

    • To determine whether, compared to placebotreatment, administration of BCAA’s, at one or more doses, after a sports-relatedconcussion improves processing speed recovery at one or more time-periods post concussion.
    • To determine whether administration of BCAA’s improves neurocognitive recovery compared to placebo for the cognitive domains of attention, learning, and working memory; to evaluate whether BCAA supplementation improves clinical symptom resolution; and to determine whether BCAA supplementation reduces the time to return to normal activities, specifically school or work, and participationin sports.
    • To assess the safety of BCAA supplementation in concussed athletes.
    • 16-34 years old having a concussion within three days.
    Perceptions of the Facilitators and Barriers of Breastfeeding Initiation: Increasing Initiation Through a Tailored, Practice-Based Approach and Policy Interventions for African-American Mothers Principal Investigator (PI)-Tyonne Hinson

    Study Coordinator-N/A

    Phone- 267-426-5721

    Email- hinsont@email.chop.edu

    • To explore and understand human and social problems according to individuals or groups.
    • To explore general themes and current practices of African-American mothers.
    • To explore purpose factors that influence opinion, behavior, or motivation.
    • To collect information from a range of professionals who have first-hand knowledge about the breastfeeding community, perceptions of barriers and facilitators, current policy and organizational breastfeeding practices, and obstacles with implementing and amending legislation.
    • Mothers of newborns 0-3 months old.
    Project EARLY: Engagement, Assessment, Referral, and Linkage for Young Children Principal Investigator (PI)-Amanda Bennett-Palladino

    Study Coordinator-Stephanie Keys

    Phone-267-426-2263

    Email- keyssr@email.chop.edu

    • To test the effectiveness of lay-delivered case management (Family Navigation) for
      children at-risk of having an autism spectrum disorder, as defined by failing MCHAT follow up interview or identified as
      having concerns for autism by their primary care provider.
    • 18 or 24 month old at well child check.
    Pediatric Liquid Medications: Sugar Free Alternatives, Parental and Pediatricians' Attitudes Principal Investigator (PI)-Jovas Booker

    Study Coordinator-N/A

    Phone-267-331-1053

    Email- bookerj@email.chop.edu

    • To examine the attitudes of parents and pediatricians towards sugar in pediatric liquid mediations and sugar free alternatives.
    • To examine pediatricians source of
      knowledge of sugar content in medications and its relation to oral health; determine possible factors which may influence prescribing medications in sugar free forms.
    • To assess if pediatricians are providing oral health instructions after prescribing oral medications.
    • To examine the parental source of knowledge of sugar content in medications; and to increase awareness of sugar free alternatives and good oral hygiene.
    • Parents at well child visit who have received a liquid medication within the last year.
    • Providers and residents.
    Home Plate: A Randomized Controlled Trial of a Community-Engaged Intervention to Improve Home Food Preparation Practices and Health during Early Childhood Principal Investigator (PI)-Sen Virudachalam

    Study Coordinator-Gabriella John

    Phone-267-426-1171

    Email- johng@email.chop.edu

    • To improve the physical health of mothers and children, specifically related to diet and body mass index, by giving mothers the knowledge, confidence, and ability to cook regular, heathly meals for their families.
    • To improve family health related to parenting skills, hopeful patterns of thinking, and coping mechanisms.
    • To determine factors which distinguish participants who have improved diet, physical health, and family health from those who do not.
    • English speaking parent/legal guardian who are able to give informed consent for at least one child ages 1-3 years old.
    • 1-3 year old children of adult caregivers who enrolled in the study.
    • Caregivers and children without medical condition that significantly affects their diet or eating habits.
    Primary Care Drug Therapeutics CER in a Pediatric EHR Network Principal Investigator (PI)-Alex Fiks

    Study Coordinator-Stephanie Mayne

    Phone-267-426-5257

    Email- maynes@email.chop.edu

    • To conduct four of proof-of-concept CER studies on psychotropic and asthma medication use and side effects plus an additional full-scale CER study on treatment for pediatric hypertension (HTN).
    • To advance the methodology of pediatric pharmacoepidemiological CER using EHR data.
    • To provide a platform for future CER studies in pediatric drug therapeutics and other topic areas.
    • Data pulling study.
    Exome Results Evaluation Principal Investigator (PI)-Bob Grundmeier

    Study Coordinator-Dean Karavite

    Phone-267-426-7805

    Email- karavite@email.chop.edu

    • To develop better ways of supporting pediatricians as they struggle to understand and act upon genetic
      test results.
    • To better understand genetic test results.
    • To be aware of any specific care that is required for their patient's genetic diagnosis.
    • To initiate discussions with families regarding gene carrier statusetter understand genetic test results.
    • Physicians and Nurse Practitioners.