Listing

Study Name Study Contact Basic Overview Criteria
Magnetoencephalographic Studies of Lexical Processing and Abstraction in Autism Spectrum Disorders Principal Investigator (PI)-Tim Roberts

Study Coordinator-Leah Gaetz

Phone-215-590-0916

Email- MEGstudies@email.chop.edu

• To understand how a child’s brain processes sounds, words and pictures.
• To study brain activity differences between children with ASD and children with typical development.
• 6-15 years old with a diagnosis of ASD with language impairment.
• 6-15 years old.
• Typical developing.
autismMatch Principal Investigator (PI)-Robert Schultz

Study Coordinator-Lindsey Demarco

Phone-267-426-4971

Email- autism@email.chop.edu

• To connect families and individuals with ASD with autism research studies at the Center for Autism Research (CAR) and affiliated centers. • Children and adults with and without ASD.
Genetic Causes for Complex Pediatric Disorders Principal Investigator (PI)-Hakon Hakonarson

Study Coordinator-Meckenzie Behr

Phone-267-670-2322

Email- behrm@email.chop.edu

• To study genetic causes for pediatric disorders, both common and rare (Crohn’s, diabetes, ADHD and autism). • Any child and their parents willing to sign consent and have blood samples obtained.
Speech Perception and Word Learning in Early Childhood Principal Investigator (PI)-Dan Swingley

Study Coordinator-Elizabeth Crutchley

Phone-215-746-0060

Email- este@sas.upenn.edu

• To understand how infants and children acquire language.
• To discover what children know about language above and beyond what children reveal through their own speech.
• 6 months – 24 months old.
• English-speaking.
• No known major hearing loss or known significant visual impairment, no significant mental impairments.
Improving the Trajectory of Motor Development in Infants and Toddlers with Cerebral Palsy Principal Investigator (PI)-Laura Prosser

Study Coordinator-Jennifer Swope

Phone-215-301-4301

Email- swopej@email.chop.edu

• To learn how two different types of physical therapy affect motor development in toddlers who have or may have cerebral palsy. • 12-36 months old with diagnosed or suspected cerebral palsy.
The SCOUT Study Principal Investigator (PI)-Theo Zaoutis

Study Coordinator-Shawn O'Connor

Phone-267-426-5292

Email- oconnors1@email.chop.edu

• To determine if halting antimicrobial therapy in subjects who have exhibited clinical improvement 5 days after starting antibiotic therapy (short course therapy) have the same failure rate (symptomatic UTI) through TOC (visit Day 12-14) as subjects who continue to take antibiotics for an additional 5 days (standard course therapy).
• To determine if short-course therapy compared to standard course therapy results in similar numbers of children experiencing a recurrent urinary tract infection (relapse and re-infection).
• <10 years old.
• No history of prematurity.
Development of Infant Microbiome and Effect of Antibiotics Principal Investigator (PI)-Jeff Gerber

Study Coordinator-Nicole Frager

Phone-267-425-1417

Email- fragern@email.chop.edu

• To define the development of the microbiome in the first two years of life across children of
variable diet, race, and mode of delivery.
• To measure the impact of various antimicrobial exposures on the infant microbiome.
• Newborns within the first 2 weeks of life.
Youth Suicide Prevention in Primary Care Principal Investigator (PI)-Guy Diamond

Study Coordinator-Tita Atte

Phone-267-426-5104

Email- tita.atte@drexel.edu

• To train physicians in suicide risk assessment.
• To implement a web-based behavioral health screening tool into the workflow of the clinical practice.
• To improve the linkages between the practice and mental health services to that identified patients can get mental health services more easily and rapidly.
• Any youth presenting with suicidal ideation.
Heart Health Screening-ECG screeing Study Principal Investigator (PI)-Vicki Vetter

Study Coordinator-Noreen Dugan

Phone-267-424-1388

Email- dugann@email.chop.edu

• To find out if a screening test for heart disease called an electrocardiogram (ECG/EKG) can be used to identify children and adolescents, who might have a form of heart disease that puts them at risk for having a cardiac arrest. • Ages 2-6 weeks old.
• Ages 12-19 years old.
Human Microbiome in Pediatric Health and Disease Principal Investigator (PI)-Bob Baldassano

Study Coordinator-Alissa Galgano

Phone-267-426-7566

Email- galganoa@email.chop.edu

• To characterize the microbiome in healthy children and children suffering from inflammatory bowel disease with the goal of improving diagnosis and treatment of disease. • Children and young adults with no chronic health conditions (ex: asthma, eczema, diabetes, obesity).
• Children and young adults who do not have siblings with Inflammatory Bowel Disease.
• Children and young adults who have not taken oral antibiotics in the last 3 months.
Improving Adolescent Reproductive Health through Online Family Engagement: Developing the 'Parents are TALKING' Website Principal Investigator (PI)-Aletha Akers

Study Coordinator-Jennifer Harding

Phone-267-426-1214

Email- hardingj@email.chop.edu

• To conduct a pilot test of the Parents are TALKING website to assess program completion rates, user satisfaction, adolescent engagement in reproductive clinical care services, and condom/contraceptive use rates. The Parents are TALKING website is an interactive website intended to improve parents’ capacity to positively influence the reproductive health of their adolescent girls . • Parents of middle and high school aged females.
Investigation of the Gut Microbiome and Kidney Stone Disease in Children Principal Investigator (PI)-Gregory Tasian

Study Coordinator-Kristen Koepsell

Phone-267-426-5463

Email- koepsellk@email.chop.edu

• To characterize the microbiome, identify prior antibiotic use, and determine the diets of 80 children with and without kidney stones .
• To test the hypotheses that children with kidney stones have a lower abundance of a bacteria called Oxalobacter, which may protect against kidney stone formation, and that lower gut microbial diversity is associated with higher prior antibiotic use .
• Children ages 4-18 years old with/without a history of kidney stones.
Interactive point-of care digital video as a tool to improve HPV vaccination rates among adolescents Principal Investigator (PI)-Kristen Feemster

Study Coordinator-Caitlin Fasano

Phone-267-425-2445

Email- seminackc@email.chop.edu

• To assess the impact of an interactive point-of-care digital video program (RFO or Recipe for Outcomes) targeting HPV vaccines within a primary care setting. • Healthy adolescents eligible for HPV vaccination during a scheduled primary care visit.
Influenza Vaccine Responsiveness In Young Children Principal Investigator (PI)-Kristen Feemster

Study Coordinator-Valerie McGoldrick

Phone-267-425-1702

Email- mcgoldrickvm@email.chop.edu

• To compare antibodies in sera from children vaccinated with 2 doses of influenza vaccine from the same season with sera from children vaccinated with 2 doses of influenza vaccine from two different seasons.
• To determine if children mount
different immune responses following two vaccinations in the same influenza season versus two influenza vaccinations in two different influenza seasons.
• Infants at least 6 months old who have not received the influenza vaccine previously.
PriCare Study Principal Investigator (PI)-Joanne Wood

Study Coordinator-Devon Kratchman

Phone-267-425-1735

Email- PriCARE@email.chop.edu

• To evaluate the efficacy of a group parenting program, PriCARE, for parents of children ages 2-6 years old who are concerned that their child has behavioral problems. • Parents and caregivers of children ages 2-6 years old who report a behavioral concern.
Novel Imaging in Autosomal Recessive Polycystic Kidney Disease (ARPKD) Principal Investigator (PI)-Erum Hartung

Study Coordinator-N/A

Phone-267-908-2297

Email- hartunge@email.chop.edu

• To use brand-new imaging technologies to measure how severely affected the liver and kidneys are in autosomal recessive polycystic kidney disease (ARPKD). • Less than 21 years old.
• No history of kidney or liver disease, high blood pressure, blood or autoimmune diseases or obesity.
• No close relatives (siblings or parents) with kidney or liver disease.
Muscle Accrual and Function in Cystic Fibrosis-Impact of Glucose Intolerance Principal Investigator (PI)-Saba Sheikh

Study Coordinator-Christina Kubrak

Phone-267-426-5135

Email- kubrak@email.chop.edu

• To assess differences in lean muscle mass, muscle function and fat deposition in muscles between adolescents and young adults with Cystic Fibrosis (CF) and healthy individuals. • Teens/young adults ages 16-22 years old with diagnosed or suspected CF.
SPARK Study Principal Investigator (PI)-Carole Marcus

Study Coordinator-Ruth Bradford

Phone-267-426-5747

Email- bradford@email.chop.edu

• To determine the efficacy of NCS vs. placebo in treating OSAS in children.
• To determine which factors modify the response to NCS, to determine the long-term effect of NCS vs. placebo in the treatment of OSAS in children to determine the side-effects associated with chronic NCS use in children with OSAS.
• 5-10 years old with mild to moderate OSAS.
• No history of adenotonsillectomy or recent prior nasal steroid use.
Electrophysiological Signatures of language impairment in Autism Spectrum Disorder Principal Investigator (PI)-Tim Roberts

Study Coordinator-Leah Gaetz

Phone-267-426-4914

Email- gaetzl@email.chop.edu

• To understand more about how a child's brain processes sounds, words and pictures. Specifically, to look at the differences between children with Autism Spectrum Disorders and children who are typically developing. • Children between the ages of 8-12 years old who have a diagnosis of ASD and who are typically developing.
ROADD Study Principal Investigator (PI)-Juhi Pandey

Study Coordinator-Meredith Cola

Phone-267-425-1187

Email- roadd@email.chop.edu

• To determine how children with Autism Spectrum Disorder (ASD) differ from children who are typically developing with respect to: (a) cognitive/behavioral measures of the ASD phenotype; (b) electro- and psychophysiological measures of brain functioning; (c) within-group correlations between behavioral deficits, and biological factors. • Toddlers ages 2-5 years old with autism spectrum disorder (ASD) or developmental delay.
• Toddlers ages 2-5 years old who are typically developing.
Linking, Obesity, Immune Dysfunction and Infection (waiting IRB approval) Principal Investigator (PI)-E. John Wherry

Co-Investigator-Sarah Henrickson

Study Coordinator-N/A

Phone-215-300-7986

Email- henricksons@email.chop.edu

• To understand the effect of obesity and asthma on children's ability to respond to their childhood vaccinations and fight infections.
• To understand the effect of obesity and asthma on the immune system.
• Healthy 6-18 years old.
• Weight-<85% or >=95%.
Sleep, Behavior, and Early Childhood Sleep Screening: An Intervention in Primary Care Principal Investigator (PI)-Carol Marcus

Study Coordinator-Ariel Williamson

Phone-267-702-0260

Email- williamsona@email.chop.edu

• To identify sleep habits and to determine the impact of sleep problems on behavior among 150 young children ages 2 to 5 years presenting to the three proposed urban pediatric primary care clinic settings for Well Child Visits (WCVs). This objective will help to identify the rates of sleep problems in these settings. Families with young children will be approached in the primary care waiting rooms and asked if (a) they have a child between the ages of 2 and 5 years present for a visit, and (b) if so, if they would like to participate in a brief 20-30 minute paper and pencil survey on sleep habits and behavior while they are waiting for their WCV. • Children ages 2-5 years old.
A Phase IV Double-Blind, Placebo-Controlled, Randomized Trial to Evaluate Short Course vs. Standard Course Outpatient Therapy of Community Acquired Pneumonia in Children (SCOUT-CAP) Principal Investigator (PI)-Jeff Gerber

Study Coordinator- Kellie Liston

Phone-267-425-1453

Email- listonk@email.chop.edu

• To determine the overall outcome of children aged 6-71 months with community-acquired pneumonia (CAP) assigned to either short course (5 days) versus standard course (10 days) of therapy. • Children ages 6-71 months diagnosed with community acquired pneumonia.
Optical Measurement of Cerebral Hemodynamics in Children with Acute Arterial Ischemic Stroke Principal Investigator (PI)-Dan Licht

Study Coordinator-Tim Boorady

Phone- 215-590-3520

Email- booradyt@email.chop.edu

• The primary objectives are to determine the variability of CBF in healthy children as HOB position is altered and to determine whether noninvasive monitoring with optical spectroscopy can detect changes in cerebral blood flow as the HOB angle is varied over a range from -5 to +30 degrees in children with ischemic stroke.
• The secondary objective is to determine if the position that maximizes CBF varies over time from stroke onset.
• Healthy children ages 2-18 years old.
Airway Microbiome and Age 6y/o Asthma Phenotypes in 2 Diverse Multicenter Cohorts Principal Investigator (PI)-Jonathan Spergel

Study Coordinator-Sasha Tilles

Phone-215-749-0410

Email- tilless@email.chop.edu

• To investigate the association between airway microbiome during early infancy and risk of developing childhood asthma. • Healthy infants age 3 months old .
HIT HEADS: Head Injury Treatment with Healthy and Advanced Dietary Supplements for Sports-Related Concussion Principal Investigator (PI)-Matt Kircshen

Study Coordinator- TBD

Phone- TBD

Email- TBD

• To determine whether, compared to placebotreatment, administration of BCAA’s, at one or more doses, after a sports-relatedconcussion improves processing speed recovery at one or more time-periods post concussion.
• To determine whether administration of BCAA’s improves neurocognitive recovery compared to placebo for the cognitive domains of attention, learning, and working memory; to evaluate whether BCAA supplementation improves clinical symptom resolution; and to determine whether BCAA supplementation
reduces the time to return to normal activities, specifically school or work, and participationin sports.
• To assess the safety of BCAA supplementation in concussed athletes.
• 16-34 years old having a concussion within three days.
Parent eReferral to Tobacco Quitline in Primary Care Principal Investigator (PI)-Brian Jenssen

Study Coordinator-N/A

Phone-215-553-4390

Email- jenssenb@email.chop.edu

• To compare through a randomized clinical trial parent smoker enrollment in the tobacco quitline using an electronic referral process (parent information sent to quitline with quitline calling the parent) to the current standard manual process (giving the parent the quitline phone number).
• To explore parent and child factors associated with successful enrollment in and willingness to receive services from the tobacco quitline in order to inform future interventions that maximize impact.
• Parents who report they want to quit smoking.
Project EARLY: Engagement, Assessment, Referral, and Linkage for Young Children Principal Investigator (PI)-Amanda Bennett-Palladino

Study Coordinator-Manju Abrahams

Phone-267-426-2263

Email- abrahammm@email.chop.edu

• To test the effectiveness of lay-delivered case management (Family Navigation) for
children at-risk of having an autism spectrum disorder, as defined by failing MCHAT follow up interview or identified as
having concerns for autism by their primary care provider.
• 18 or 24 month old at well child check.
MEG Studies of Auditory Processing in Minimally/Non-Verbal Children with ASD and Intellectual Disability Principal Investigator (PI)-Tim Roberts

Study Coordinator-Ayesha Anwar

Phone-267-425-2236

Email- anwara@email.chop.edu

• To determine if neural biomarkers are generalizable to lower- functioning autism spectrum disoder (ASD) (specifically, minimally/non-verbal). • Children 8-12 years old who have non-verbal ASD and intellectually delayed children without ASD .
Exome Results Evaluation Principal Investigator (PI)-Bob Grundmeier

Study Coordinator-Dean Karavite

Phone-267-425-1667

Email- karavite@email.chop.edu

• To develop better ways of supporting pediatricians as they struggle to understand and act upon genetic test results.
• To better understand genetic test results.
• To be aware of any specific care that is required for their patient's genetic diagnosis.
• To initiate discussions with families regarding gene carrier statusetter understand genetic test results.
• Physicians and Nurse Practitioners.
Impact of Treatment of Mild Sleep Disorder Breathing on Children's Health (PAT-S) Principal Investigator (PI)-Carole Marcus

Study Coordinator-Laurie Karamessinis

Phone-215-590-9184

Email- karamessil@email.chop.edu

• To study the effect of adenotonsillectomy on children with snoring. • 3-9 years old.
The Impact of Paternal Childhood Adversity on Offspring Health-Case Control Study Principal Investigator (PI)-Roy Wade

Study Coordinator-Danielle Collins

Phone-267-425-1503

Email- collinsd2@email.chop.edu

• To examine the association between paternal childhood adversity and offspring behavioral/mood problems, cognitive
problems, and chronic health problems by age 8 years old. • Parents.
Doctor-Patient Communication about Development Principal Investigator (PI)-Susan Levy

Study Coordinator-Kate Wallis

Phone-267-496-5469

Email- wallisk@email.chop.edu

• To understand doctor-patient communication in pediatric primary care about developmental concerns. • Primary care providers and children ages 18-30 months old.
Weight Gain, Bone Geometry, and Functional Body Composition in Adolescents with Anorexia Nervosa Principal Investigator (PI)-Rebecka Peebles

Study Coordinator-Courtney Cheek-Park

Phone-267-426-3934

Email- parkcc@email.chop.edu

• To learn how weight gain during treatment for any restrictive eating disorder affects a patient’s metabolism, bone health, and muscle strength. • Patients ages of 10-24 years old being treated at CHOP for any type of restrictive eating disorder. .
Mechanisms of Obstructive Sleep Apnea Syndrome in Infants with Micrognathia Principal Investigator (PI)-Chris Cielo

Study Coordinator-Mary Anne Cornaglia

Phone-267-426-5748

Email- cornaglia@email.chop.edu

• To better understand why some children with conditions causing a small jaw (micrognathia) have breathing problems during sleep. • Healthy patients.
Gamification and Energetic Behavior Changes in Adolescent-Parent Dyads with Obesity Principal Investigator (PI)-Liz Parks-Prout

Study Coordinator-Yasmeen Bruton

Phone-267-426-7139

Email- brutony@email.chop.edu

• To test if using a Fitbit to monitor steps per day, and getting points and medals based on steps accrued performance through an online game, can help obese parents and children become more physically active. Likewise, the GAME Study is using the same approach to learn if gamification can also help obese parents and children reduce their sugar sweetened beverage consumption. • Children ages 10-16 years old with a BMI >95%.
Autism Spectrum Disorder Screening in a Large Primary Care Network: Using a Smartphone App to Gather Objective Data at Home, Expand Screening to Preschoolers, and Verify Long Term Outcomes Through The Electronic health Record Principal Investigator (PI)-Judi Miller

Study Coordinator-Becca Thomas

Phone- 267-425-1160

Email- thomasrp@email.chop.edu

• To focus on false negatives. It is precisely this group for whom screening needs to improve –children who screen negative but go on to develop ASD.
• To create objective measures integrated into screening. Current tools rely on caregivers and providers to make behavioral observations that can be difficult even for trained specialists.
• To create tools to expand ASD screening beyond the 16-30 month age range, since the median age of first ASD evaluation is 40 months.
• All children and families.
Development of a National Youth Firearm Risk and Safety Assessment Tools Principal Investigator (PI)-Roy Wade

Study Coordinator-Danielle Collins

Phone-267-425-1503

Email- collinsd2@email.chop.edu

• To develop and pilot a comprehensive youth firearm violence exposure instrument, the Youth Firearm Risk and Safety Tool (Youth-FiRST), enabling much needed research on youth firearm exposure, health-related outcomes, and effective prevention and intervention strategies. • Youth/adolescents ages 2-17 years old and their parent/caregivers.
Reliability and Validity of Brief Game Screen of PTSD for Children Principal Investigator (PI)-Billie Schwartz

Study Coordinator-N/A

Phone-267-426-2868

Email- schwartzb@email.chop.edu

• To test a mobile game that briefly assesses for posttraumatic stress disorder (PTSD) in children aged 8-12 years old. The game utilizes 6 screening items taken from a broader self-report questionnaire screen (CPSS-5-SR) for PTSD.. • All children ages 8-12 years old.
Pediatrician Message Framing to Protect Children from Secondhand Smoke Exposure Principal Investigator (PI)-Brian Jenssen

Study Coordinator-N/A

Phone-215-553-4390

Email- jenssenb@email.chop.edu

• To develop an evidence-based message framing approach to promote parental tobacco cessation treatment in the pediatric setting.
• To identify patient and parent factors associated with different patterns of responsiveness to different message frames.
• To examine the association between message frame selection and subsequent tobacco cessation behavior.
• Parents and caregivers.
Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants with Infantile Hemangioma (IH) Principal Investigator (PI)-Jenna Streicher

Study Coordinator-Donnette Paris

Phone-267-426-7167

Email- paris@email.chop.edu

• To find out if the investigational drug, Timolol will decrease the hemangioma color and size when applied to the skin over the hemangioma. • Infants with newly diagnosed IH.
Beds for Kids Program: Impact on Child Sleep and Family Functioning in Young Children Principal Investigator (PI)-Jodi Mindell

Study Coordinator- Ariel Williamson

Phone-267-702-0260

Email- williamsona@email.chop.edu

• To evaluate the impact of provision of a child bed through the Beds for Kids program on objectively measured child sleep, and on daily child behavioral functioning, caregiver mood, and caregiver sleep over 14 days for preschool-aged children.
• To determine the impact of poor child sleep (short sleep duration, later bedtimes, inconsistent bedtimes, night wakings, and poor sleep quality) on daily child behavior, caregiver mood, and caregiver sleep.
• To determine the impact of provision of a child bed through the Beds for Kids program on child sleep at one-month follow-up (one-month post-bed delivery).
• Children ages 2-5 years old.