Listing

Study Name Study Contact Basic Overview Criteria
Magnetoencephalographic Studies of Lexical Processing and Abstraction in Autism Spectrum Disorders Principal Investigator (PI)-Tim Roberts

Study Coordinator-Leah Gaetz

Phone-215-590-0916

Email- MEGstudies@email.chop.edu

• To understand how a child’s brain processes sounds, words and pictures.
• To study brain activity differences between children with ASD and children with typical development.
• 6-15 years old with a diagnosis of ASD with language impairment.
• 6-15 years old.
• Typical developing.
autismMatch Principal Investigator (PI)-Robert Schultz

Study Coordinator-Lindsey Demarco

Phone-267-426-4971

Email- autism@email.chop.edu

• To connect families and individuals with ASD with autism research studies at the Center for Autism Research (CAR) and affiliated centers. • Children and adults with and without ASD.
Genetic Causes for Complex Pediatric Disorders Principal Investigator (PI)-Hakon Hakonarson

Study Coordinator-Meckenzie Behr

Phone-267-670-2322

Email- behrm@email.chop.edu

• To study genetic causes for pediatric disorders, both common and rare (Crohn’s, diabetes, ADHD and autism). • Any child and their parents willing to sign consent and have blood samples obtained.
Speech Perception and Word Learning in Early Childhood Principal Investigator (PI)-Dan Swingley

Study Coordinator-Elizabeth Crutchley

Phone-215-746-0060

Email- este@sas.upenn.edu

• To understand how infants and children acquire language.
• To discover what children know about language above and beyond what children reveal through their own speech.
• 6 months – 24 months old.
• English-speaking.
• No known major hearing loss or known significant visual impairment, no significant mental impairments.
Improving the Trajectory of Motor Development in Infants and Toddlers with Cerebral Palsy Principal Investigator (PI)-Laura Prosser

Study Coordinator-Jennifer Swope

Phone-267-426-7803

Email- swopej@email.chop.edu

• To learn how two different types of physical therapy affect motor development in toddlers who have or may have cerebral palsy. • 12-36 months old with diagnosed or suspected cerebral palsy.
The SCOUT Study Principal Investigator (PI)-Theo Zaoutis

Study Coordinator-Shawn O'Connor

Phone-267-426-5292

Email- oconnors1@email.chop.edu

• To determine if halting antimicrobial therapy in subjects who have exhibited clinical improvement 5 days after starting antibiotic therapy (short course therapy) have the same failure rate (symptomatic UTI) through TOC (visit Day 12-14) as subjects who continue to take antibiotics for an additional 5 days (standard course therapy).
• To determine if short-course therapy compared to standard course therapy results in similar numbers of children experiencing a recurrent urinary tract infection (relapse and re-infection).
• <10 years old.
• No history of prematurity.
Efficacy of Antibiotics in Children with Sinusisits: Children Benefit? Principal Investigator (PI)-Theo Zaoutis

Study Coordinator-Laura Anatale-Tardiff

Phone-215-590-6785

Email- anataletal@email.chop.edu

• To determine the efficacy of antibiotic therapy in children 2 to 12 years of age with persistent or worsening presentations of acute sinusitis.
• To determine subgroups of children with acute sinusitis that are unlikely to benefit from antimicrobial therapy.
• 2-12 years with diagnosed acute sinusitis.
Youth Suicide Prevention in Primary Care Principal Investigator (PI)-Guy Diamond

Study Coordinator-Tita Atte

Phone-215-571-3416

Email- tita.atte@drexel.edu

• To train physicians in suicide risk assessment.
• To implement a web-based behavioral health screening tool into the workflow of the clinical practice.
• To improve the linkages between the practice and mental health services to that identified patients can get mental health services more easily and rapidly.
• Any youth presenting with suicidal ideation.
Heart Health Screening-ECG screeing Study Principal Investigator (PI)-Vicki Vetter

Study Coordinator-Noreen Dugan

Phone-267-426-5247

Email- dugann@email.chop.edu

• To find out if a screening test for heart disease called an electrocardiogram (ECG/EKG) can be used to identify children and adolescents, who might have a form of heart disease that puts them at risk for having a cardiac arrest. • Ages 2-6 weeks old.
• Ages 12-19 years old.
Microbiome Study Principal Investigator (PI)-Bob Baldassano

Study Coordinator-Sarah Marakos

Phone-267-426-7566

Email- marakoss@email.chop.edu

• To characterize the microbiome in healthy children and children suffering from inflammatory bowel disease with the goal of improving diagnosis and treatment of disease. • Children and young adults with no chronic health conditions (ex: asthma, eczema, diabetes, obesity).
• Children and young adults who do not have siblings with Inflammatory Bowel Disease.
• Children and young adults who have not taken oral antibiotics in the last 3 months.
Cardiometabolic risk and obesity in adolescents with Down syndrome Principal Investigator (PI)-Sheela Magge

Study Coordinator-Claire Cochrane

Phone-267-426-2778

Email- cochranec@email.chop.edu

• To compare the relationship between BMI-Z score and cardiometabolic risk factors in youth with DS, and in age, sex, race, ethnicity and BMI-Z score matched controls.
• To examine the relationship between obesity, lifestyle (physical activity, nutrition), body image, and quality of life in DS, and to explore barriers to maintaining a healthy weight in children with DS.
DS Group
• Males and females age 10 to 20 years.
• Diagnosis of DS.
• Parental/guardian permission (informed consent) and if appropriate, child assent.
• Males and females age 10 to 20 years.
• Parental/guardian permission (informed consent) and if appropriate, child assent.
 
Understanding Healthcare Utilization Behaviors for Pediatric Patients and Their Caregivers Principal Investigator (PI)-Joel Fein

Study Coordinator-Whitney Cabey

Phone-215-573-2573

Email- cabeyw@email.chop.edu

• To understand how parents and caregivers make decisions about where to get health care for children when they are sick . • Parents and caregivers.
Dietary Fructose, Zinc, and Nephrolithiasis Principal Investigator (PI)-Gregory Tasian>

Study Coordinator-Steven Warner

Phone-267-225-4527

Email- warners1@email.chop.edu

• To determine the differences in fructose and zinc intake between adolescents with and without calcium oxalate nephrolithiasis.
• To determine the relationship between dietary fructose and zinc intake and urine chemistries among adolescents.
• Healthy adolescents ages 12-18 years old.
Interactive point-of care digital video as a tool to improve HPV vaccination rates among adolescents Principal Investigator (PI)-Kristen Feemster

Study Coordinator-Caitlin Fasano

Phone-215-590-9366

Email- fasanoce@email.chop.edu

• To assess the impact of an interactive point-of-care digital video program (RFO or Recipe for Outcomes) targeting HPV vaccines within a primary care setting. • Healthy adolescentseligible for HPV vaccination during a scheduled primary care visit.
Influenza Vaccine Responsiveness In Young Children Principal Investigator (PI)-Kristen Feemster

Study Coordinator-Jacqueline Dim

Phone-267-426-9561

Email- dimj@email.chop.edu

• To compare antibodies in sera from children vaccinated with 2 doses of influenza vaccine from the same season with sera from children vaccinated with 2 doses of influenza vaccine from two different seasons.
• To determine if children mount different immune responses following two vaccinations in the same influenza season versus two influenza vaccinations in two different influenza seasons.
• Infants at least 6 months old who have not received the influenza vaccine previously.
PriCare Study Principal Investigator (PI)-Joanne Wood

Study Coordinator-Jennifer Chapman

Phone-267-426-1247

Email- PriCARE@email.chop.edu

• To evaluate the efficacy of a group parenting program, PriCARE, for parents of children ages 2-6 years old who are concerned that their child has behavioral problems. • Parents and caregivers of children ages 2-6 years old who report a behavioral concern.
Novel Imaging in Autosomal Recessive Polycystic Kidney Disease (ARPKD) Principal Investigator (PI)-Erum Hartung

Study Coordinator-N/A

Phone-267-908-2297

Email- hartunge@email.chop.edu

• To use brand-new imaging technologies to measure how severely affected the liver and kidneys are in autosomal recessive polycystic kidney disease (ARPKD). • Less than 21 years old.
• No history of kidney or liver disease, high blood pressure, blood or autoimmune diseases or obesity.
• No close relatives (siblings or parents) with kidney or liver disease.
SNAP Study Principal Investigator (PI)-Meg Oberle

Study Coordinatorn-N/A

Phone-267-331-1233

Email- oberlem@email.chop.edu

• To characterize the quality of the diet and how people purchase food across a monthly Supplemental Nutrution Assistance Program (SNAP) cycle.
• To evaluate the effect of eating patterns on appetite regulating hormones.
• To understand what neighborhoods people are shopping and why over the monthly SNAP cycle for study participants.
• Mothers who receive SNAP benefits.
SPARKS Principal Investigator (PI)-Carole Marcus

Study Coordinator-Ruth Bradford

Phone-267-426-5747

Email- bradford@email.chop.edu

• To determine the efficacy of NCS vs. placebo in treating OSAS in children.
• To determine which factors modify the response to NCS, to determine the long-term effect of NCS vs. placebo in the treatment of OSAS in children to determine the side-effects associated with chronic NCS use in children with OSAS.
• 5-10 years old with mild to moderate OSAS.
• No history of adenotonsillectomy or recent prior nasal steroid use.
Waiting Room Survey-Mobile Health Apps Principal Investigator (PI)-Alex Fiks

Study Coordinator-Lindsay Berrigan

Phone-267-426-7561

Email- berriganl@email.chop.edu

• To survey parents and learn about what mobile devices (smartphones, tablets) and apps parents are using for their children's health, and what types of apps they would want to use in the future. • Any willing parent or caregiver participant.
ROADD Study Principal Investigator (PI)-Juhi Pandey

Study Coordinator-Meredith Cola

Phone-267-426-3948

Email- roadd@email.chop.edu

• To determine how children with Autism Spectrum Disorder (ASD) differ from children who are typically developing with respect to: (a) cognitive/behavioral measures of the ASD phenotype; (b) electro- and psychophysiological measures of brain functioning; (c) within-group correlations between behavioral deficits, and biological factors. • Toddlers ages 2-5 years old with autism spectrum disorder (ASD) or developmental delay.
• Toddlers ages 2-5 years old who are typically developing.
Linking, Obesity, Immune Dysfunction and Infection Principal Investigator (PI)-E. John Wherry
Co-Investigator-Sarah Henrickson

Study Coordinator-Donnette Paris

Phone-267-426-7167

Email- paris@email.chop.edu

• To understand the effect of obesity and asthma on children's ability to respond to their childhood vaccinations and fight infections.• To understand the effect of obesity and asthma on the immune system. • Healthy 6-18 years old.• Weight-<85% or >=95%.
Adapting Behvior Change Interventions for Use in Primary Care Principal Investigator (PI)-Carol Ford

Study Coordinator-Elizabeth Friedrich

Phone-215-590-3293

Email- friedriche@email.chop.edu

• To get parent's opinions about the content of parent-based intervention materials related to teen health behaviors.
• To gahter parent's ideas about how best to give out the intervention materials in primary care settings.
• To get parent's feedback about participation in research related to teen health behaviors.
• To create materials that are useful and acceptable to parents and that may be easily delivered in healthcare settings based on the information gathered.
• Parent's of 12-17 year olds.
The Development of Tests of Lung Function in Preschool Children with Asthma Principal Investigator (PI)-Julian Allen

Study Coordinator-Diana Worsley

Phone-267-426-9206

Email- worsleyd@email.chop.edu

• To assess the usefulness and accuracy of two different types of lung function testing in preshcool children. • 16 year old or older that had a sports physical in the last year or two.
Optical Measurement of Cerebral Hemodynamics in Children with Acute Arterial Ischemic Stroke Principal Investigator (PI)-Dan Licht

Study Coordinator-Kobina Mensah-Brown

Phone- 215-590-3966

Email- mensahbrok@email.chop.edu

• The primary objectives are to determine the variability of CBF in healthy children as HOB position is altered and to determine whether noninvasive monitoring with optical spectroscopy can detect changes in cerebral blood flow as the HOB angle is varied over a range from -5 to +30 degrees in children with ischemic stroke.
• The secondary objective is to determine if the position that maximizes CBF varies over time from stroke onset.
• Healthy children ages 2-18 years old.
The Human Immune Response to Chlamydia Trachomatis Principal Investigator (PI)-Laura Vella

Study Coordinator-Laura Vella

Phone-412-848-7461

Email- vellal@email.chop.edu

• To provide information that will help make a vaccine to prevent Chlamydia infection. The body has difficulty fighting off the Chlamydia bacteria, and a person can get have the infection for a long well against Chlamydia. We also want to see which protein parts of the Chlamydia are the easiest for the immune
system to fight.
• Males or Females presenting without parent to the Family Planning Clinic with indication fro Chlamydia testing and HIV testing.
• Ability of the minor to consent for him or herself.
HIT HEADS: Head Injury Treatment with Healthy and Advanced Dietary Supplements for Sports-Related Concussion Principal Investigator (PI)-Matt Kircshen

Study Coordinator-Mary Ann Diliberto

Phone-267-426-5753

Email- diliberto@email.chop.edu

• To determine whether, compared to placebotreatment, administration of BCAA’s, at one or more doses, after a sports-related concussion improves processing speed recovery at one or more time-periods post concussion.
• To determine whether administration of BCAA’s improves neurocognitive recovery compared to placebo for the cognitive domains of attention, learning, and working memory; to evaluate whether BCAA supplementation improves clinical symptom resolution; and to determine whether BCAA supplementation
reduces the time to return to normal activities, specifically school or work, and participation in sports.
• To assess the safety of BCAA supplementation in concussed athletes.
• 16-34 years old having a concussion within three days.
Perceptions of the Facilitators and Barriers of Breastfeeding Initiation: Increasing Initiation Through a Tailored, Practice-Based Approach and Policy Interventions for African-American Mothers Principal Investigator (PI)-Tyonne Hinson

Study Coordinator-N/A

Phone- 267-426-5721

Email- hinsont@email.chop.edu

• To explore and understand human and social problems according to individuals or groups.
• To explore general themes and current practices of African-American mothers.
• To explore purpose factors that influence opinion, behavior, or motivation.
• To collect information from a range of professionals who have first-hand knowledge about the breastfeeding community, perceptions of barriers and facilitators, current policy and organizational breastfeeding practices, and obstacles with implementing and amending legislation.
• Mothers of newborns 0-3 months old.
Project EARLY: Engagement, Assessment, Referral, and Linkage for Young Children Principal Investigator (PI)-Amanda Bennett-Palladino

Study Coordinator-Manju Abrahams

Phone-267-426-2263

Email- abrahammm@email.chop.edu

• To test the effectiveness of lay-delivered case management (Family Navigation) for children at-risk of having an autism spectrum disorder, as defined by failing MCHAT follow up interview or identified as having concerns for autism by their primary care provider. • 18 or 24 month old at well child check.
Home Plate: A Randomized Controlled Trial of a Community-Engaged Intervention to Improve Home Food Preparation Practices and Health during Early Childhood Principal Investigator (PI)-Sen Virudachalam

Study Coordinator-Gabriella John

Phone-267-426-1171

Email- johng@email.chop.edu

• To improve the physical health of mothers and children, specifically related to diet and body mass index, by giving mothers the knowledge, confidence, and ability to cook regular, heathly meals for their families.
• To improve family health related to parenting skills, hopeful patterns of thinking, and coping mechanisms.
• To determine factors which distinguish participants who have improved diet, physical health, and family health from those who do not.
• English speaking parent/legal guardian who are able to give informed consent for at least one child ages 1-3 years old.
• 1-3 year old children of adult caregivers who enrolled in the study.
• Caregivers and children without medical condition that significantly affects their diet or eating habits.
Primary Care Drug Therapeutics CER in a Pediatric EHR Network Principal Investigator (PI)-Alex Fiks

Study Coordinator-Stephanie Mayne

Phone-267-426-5257

Email- maynes@email.chop.edu

• To conduct four of proof-of-concept CER studies on psychotropic and asthma medication use and side effects plus an additional full-scale CER study on treatment for pediatric hypertension (HTN).
• To advance the methodology of pediatric pharmacoepidemiological CER using EHR data.
• To provide a platform for future CER studies in pediatric drug therapeutics and other topic areas.
• Data mining study.
Exome Results Evaluation Principal Investigator (PI)-Bob Grundmeier

Study Coordinator-Dean Karavite

Phone-267-426-7805

Email- karavite@email.chop.edu

• To develop better ways of supporting pediatricians as they struggle to understand and act upon genetic test results.
• To better understand genetic test results.
• To be aware of any specific care that is required for their patient's genetic diagnosis.
• To initiate discussions with families regarding gene carrier statusetter understand genetic test results.
• Physicians and Nurse Practitioners.
Impact of Treatment of Mild Sleep Disorder Breathing on Children's Health (PAT-S) Principal Investigator (PI)-Carole Marcus

Study Coordinator-Laurie Karamessinis

Phone-215-590-9184

Email- karamessil@email.chop.edu

• To study the effect of adenotonsillectomy on children with snoring. • 3-9 years old.
Diagnostic Driving: Real Time Driver Condition Detection through Analysis of Driving Behavior Principal Investigator (PI)-Patty Huang

Study Coordinator-Chelsea Ward

Phone-215-590-1244

Email- DrivingSimulator@email.chop.edu

• The determine the feasibility of using machine learning approaches to automatically detect the medical state of the driver based on driving behaviors. • 17-24 years old.